Niacinamide - Inspira Nutritionals


, 3 min reading time

Antiaging  Superstar

Also known as: vitamin B3, nicotinamide

Main Benefit:

Cell-communicating ingredient, skin brightening, anti-acne, moisturizer/humectant


A multi-functional skincare superstar with several proven benefits for the skin

Great anti-aging, wrinkle smoothing ingredient used at 4-5% concentration

Fades brown spots alone or in combination with amino sugar, acetyl glucosamine

Increases ceramide synthesis that results in a stronger, healthier skin barrier and better skin hydration

Can help to improve several skin conditions including acne, rosacea, and atopic dermatitis


Let's look at all those skin benefits:

 #1: Anti-aging, wrinkle-smoothing properties: With age, our skin tends to slow down in many ways. One of them is in producing important proteins, such as keratin, filaggrin, and involucrin, at a slower rate. Reduced amounts of these proteins results in poorer skin structure, reduced skin elasticity, and more wrinkles. Studies show that niacinamide can boost collagen production as well as the production of these three important proteins. That means improved skin structure and fewer wrinkles. FYI, anti-aging studies usually use 4-5% niacinamide daily for 8-12 weeks, so if you are after the anti-aging benefits try to choose a product that tells you the exact percentage of niacinamide it contains.


#2: Skin-lightening Properties: Hyperpigmentation or brown spots are really stubborn and honestly it can be really hard to make them disappear just by topical products. What you can expect for them is to fade a little and niacinamide is a great ingredient to help with that.

Studies show that 2-5% Niacinamide used daily for 8 weeks results in significant lightening of hyperpigmentation.

When combined with amino sugar, acetyl glucosamine the results are even better.  What's more, niacinamide as a skin lightener works in a way different to most others. It suppresses the transfer of melanosomes (little spheres carrying the melanin pigment) from melanocytes (skin cells producing the melanin) to keratinocytes (skin cells in the top layer of the skin) while most other skin lighteners block an enzyme called tyrosinase (that plays an important role in melanin production). So if you want to mount a multi-front attack on the brown spots you can combine a niacinamide treatment with tyrosinase inhibitors like Vitamin C, Arbutin or Kojic acid.


#3: Barrier Repair Functions: the skin barrier is the outer layer of the skin that is amazingly important at keeping the skin hydrated and healthy. The stuff between the skin cells consists mainly of free fatty acids, cholesterol, and ceramides. The amount and structure of these determine how healthy the skin barrier is. What studies have shown is that 2% niacinamide can increase the synthesis of free fatty acids, cholesterol, and ceramides that result in healthier and stronger skin barrier, decreased trans-epidermal water loss and better hydrated skin.


#4: Anti-acne Properties: though Niacinamide does not count as one of the gold standard anti-acne ingredients, if you have problem skin it's totally worth a try. It has sebum regulating and anti-inflammatory properties and a study that used 4% Niacinamide for 8 weeks to treat acne found that 82% of those treated showed some improvement. What's more, the results were slightly better than with a 1% clindamycin gel, an antibiotics often used to treat acne.


#5: Other Notable Things: if the above four things are not  enough to convince you about niacinamide here are some more reasons! :) 

Studies have shown that Vitamin B3 can help to speed up epidermal cell growth (that slows down with age), it can help with wound healing, it can smooth the structure of the skin and it has also antibacterial and photo protective properties. Plus, it might also be useful for rosacea and atopic dermatitis probably because of its anti-inflammatory property.



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